Berson SR, et al. - Given that sleep-disordered breathing (SDB) patients often have normal all-night apnea-hypopnea (AHI) or respiratory-disturbance (RDI) indices on polysomnography (PSG), researchers investigated if the rapid eye motion–respiratory disturbance index (REM-RDI) may be a novel predictor of allergic status. In a retrospective analysis of 100 patient, REM-RDI results in 67 allergen-positive patients were compared with 33 nonallergic patients who presented with nasal blockage. Outcomes revealed significant bidirectional associations between allergen positivity and increased REM-RDI values independent of BMI, AHI, RDI, and REM-AHI. Allergic inflammation and REM-RDI data could play important roles in diagnosing and treating fatigued SDB patients and could be observed as objective perioperative safety and outcomes measures.