Berson SR, et al. - Authors sought to test a hypothesis that the rapid eye motion–respiratory disturbance index (REM-RDI) could be a novel predictor of allergic status. Results demonstrated notable bidirectional relationships between allergen positivity and elevated REM-RDI values independent of body mass index (BMI), apnea-hypopnea (AHI), respiratory-disturbance (RDI), and rapid eye motion (REM) - AHI. Important roles could be played by the allergic inflammation and REM-RDI data in diagnosing and treating fatigued sleep-disordered breathing cases and as objective perioperative safety and outcome measures.