Jones KM, et al. – In this overview, researchers summarizes the salient features of clinical chemical exchange saturation transfer (CEST) MRI protocols and critically assess the feasibility of CEST MRI for these clinical imaging applications. Clinicians exhibited evidence that CEST MRI tools display promise for contributing to assessments of cerebral ischemia, neurological disorders, lymphedema, osteoarthritis, muscle physiology, and solid tumors.