Kontogianni K, et al. - Researchers investigated quantitative computed tomography (QCT) and clinical parameters related to positive treatment outcome in patients who had lung volume reduction using coils (LVRC) for advanced emphysema. They analyzed data from 72 patients, focusing on the CT scans, pulmonary function tests (PFT), and 6-minute walk test (6-MWT) prior to and at 3 months after LVRC treatment. The procedure involved placing 10 coils unilaterally. They used stepwise linear regression analysis to determine independent predictors of clinically relevant outcome (Δ6-MWT ≥ 26 m, ΔFEV₁ ≥ 12%, ΔRV ≥ 10%). The identified predictors of a more positive response to LVRC treatment included presence of lower FEV₁ and 6-MWT, with higher TLC and specific QCT characteristics. These data suggested that a more targeted CT-based approach to patient selection could lead to greater efficacy in treatment response.