Piolanti N, et al. - This study entailed the comparison between two different intravenous (IV) regimens of tranexamic acid (TXA) in terms of haemostatic effect in patients who underwent primary unilateral minimally invasive total hip arthroplasty (THA). Both the TXA regimens, i.e. two IV doses of 10 mg/kg or two IV doses of 20 mg/kg, offered statistically similar results in blood loss sparing. Hence, the use of two 10 mg/kg doses could be considered more advisable in order to reduce the potential thromboembolic risks related to this drug.

Methods

• Researchers conducted a single-centre, prospective, randomized study including 80 patients who underwent primary unilateral minimally invasive THA because of a hip osteoarthritic degeneration.
• They divided patients into two groups: the G10 group received two IV doses of 10 mg/kg of TXA, and the G20 group received two doses of 20 mg/kg.

Results

• Findings demonstrated that no significant differences in mean minimum levels of Hb and HcT stratified by days after surgery were uncovered between the two groups despite the use of two different dosages of TXA.
• Researchers found that the mean blood volume loss was statistically similar between two groups.
• Also, they did not find differences regarding the occurrence of adverse effects.