Donaghy PC, et al. - For this study, experts gauged the correlation between amyloid deposition and clinical profile, gray matter volume, and brain perfusion in dementia with Lewy bodies. Patients with dementia with Lewy bodies, Alzheimer's disease and controls underwent a thorough clinical assessment, 3T MRI, and early- and late-phase ¹⁸F-Florbetapir PET-CT. No link was disclosed between amyloid deposition and differences in clinical or neuropsychological profiles in dementia with Lewy bodies. However, it appeared to be related to imaging evidence of medial temporal lobe dysfunction. Findings revealed that the presence of amyloid in dementia with Lewy bodies could not be detected based on clinical and other imaging features, but will need assessment via PET imaging or CSF.