Özçelik G, et al. - In 39 patients with childhood antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAV), researchers assessed renal prognostic factors from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS). They retrospectively analyzed demographics, clinical findings, AAV subtypes, outcomes, and FFS. During the follow-up, patients with FFS ≥ 2 vs those with FFS < 2 demonstrated remarkably higher gastrointestinal and renal involvement, myeloperoxidase (MPO)-ANCA positivity, serum creatinine levels, and impaired renal function. In biopsies, more common crescentic, mixed and sclerotic histopathologic findings were reported in patients with FFS ≥ 2. In patients with end-stage renal disease (ESRD) vs other patients, the initial level of creatinine was identified as the most robust single-risk factor among all the parameters. Overall, renal prognosis may be predicted by evaluating the FFS, ANCA serology, and the creatinine levels.