Conde-Ferreirós A, Moyano-Bueno D, Santos-Briz Á, et al. - Acantholytic cutaneous squamous cell carcinomas (aCSCC) and non-acantholytic cutaneous squamous cell carcinomas (naCSCC) have equal proportions of adverse outcomes. The acantholytic histological subtype in the cohort is not linked to a worse outcome than the non-acantholytic CSCC.

• This retrospective case-control study involved 50 aCSCC and 50 naCSCC cases.

• The mean age of the patients was 86 years (SD 9.61), with 61 of them being male.

• In high-risk head and neck areas, 39 CSCC were found.

• Twenty of the CSCCs had a low degree of differentiation, while 36 had an infiltrative growth pattern.

• The tumor thickness was 6.72 mm (IQR 15.50) and its diameter was 18.71 mm (IQR 35).

• Twelve CSCC showed perineural infiltration and 8 CSCC invasion beyond the subcutaneous fat.

• Positive tumor margins in 22 aCSCC vs 8 naCSCC after excision.

• Nineteen incidents with a bad prognosis were observed (local recurrence, lymph node metastasis, and death from CSCC).

• When comparing poor prognosis events, however, no differences were seen between the two groups.