Fredheim OM, Skulberg IM, Magelssen M, et al. - Since there exists scarce literature regarding how to use propofol in palliative sedation, so, this retrospective analysis with quantitative and qualitative data was conducted to define the patient population, previous as well as concomitant medication and clinical result when propofol was opted for palliative sedation. This study involved 14 patients who received propofol for palliative sedation. Experts noted that during manual dose titration, sedation as well as adequate symptom control was achieved in all patients. At death propofol doses ranged from 60 to 340 mg/hour. In view of the findings, it was concluded that the use of propofol for palliative sedation can afford a successful treatment of severe suffering at the end of life. Although this can be done in palliative medicine wards, but the necessity for skilled observation as well as dose titration throughout the period of palliative sedation can not be overlooked. Uninterrupted sedation until death was not promised by successful initial sedation.