Pampena R, Lai M, Lombardi M, et al. - A systematic review was conducted to determine the main clinical and dermoscopic features of the most frequently reported but uncommon histologic variants of cutaneous melanoma. This study was performed from inception to November 2018 using PubMed, Embase, and Cochrane Central Register of Controlled Trials databases. Researchers enrolled a total of 62 articles including 433 melanoma cases. It is demonstrated that uncommon melanoma variants may resemble both inflammatory disorders and other cutaneous neoplasms, representing a distinguishing pitfall even for the most experienced dermatologist. They sought to give an extensive and detailed overview of specific clinical and dermoscopic features of each uncommon melanoma variant, presenting the main criteria for differentiating these variants from other benign or malignant skin lesions.