Livingston G, et al. - In view of distressing and costly agitation symptoms among many people with dementia living in care homes, researchers developed and piloted a manual-based intervention (Managing Agitation and Raising Quality of Life in dementia; MARQUE) comprising six sessions, delivered by supervised non-clinical psychology graduates. In this trial, they examined how the MARQUE intervention influenced agitation in residents with dementia after 8 months compared with treatment as usual (TAU). Ten care homes (189 residents) were randomized to the MARQUE intervention and ten care homes (215 residents) to TAU between June 14, 2016, and July 4, 2017. Findings do not support the efficacy of the MARQUE intervention for agitation despite its feasibility and cost-effectiveness in terms of quality of life. Delivery by a professional staff of more intensive intervention, implementing social and activity times, and a longer time to implement change, might be required to address agitation in care homes.