Elgendy IY, Gad MM, Elgendy AY, et al. - Researchers analyzed randomized controlled trials comparing drug‐coated balloons (DCBs) with stents or angioplasty for de novo coronary lesions, via this meta‐analysis, to ascertain the role of DCBs in the management of de novo coronary lesions. They analyzed 14 randomized controlled trials including 2,483 patients, with target lesion revascularization being the primary outcome. These studies were identified by exploring electronic databases and major conference proceedings. DCBs were found to be related to lower target lesion revascularization vs bare metal stents and similar target lesion revascularization vs drug‐eluting stents. In terms of major adverse cardiac events, vessel thrombosis, or cardiovascular mortality, no disparity was evident between DCBs and control. However, a lower incidence of myocardial infarction as well as all‐cause mortality was reported in relation to DCBs. Overall, the use of DCBs was shown to be related to comparable clinical results, regardless of the indication or comparator device, among patients experiencing de novo coronary lesions. A similar rate of target lesion revascularization was reported for DCBs vs drug‐eluting stents.