Scicluna BP, et al. - Biologically relevant molecular endotypes were identified in sepsis patients included in this present investigation. This study successfully detected 4 molecular endotypes for sepsis, designated Mars1–4, which were associated with 28-day mortality. This investigation offers a method for the molecular classification of patients with sepsis to four different endotypes upon intensive care unit (ICU) admission. As per observations, detection of sepsis endotypes might assist in providing personalised patient management and in selection for trials.