Gutierrez J, Gil-Guevara A, Ramaswamy S, et al. - Using brain MRI from 1,290 stroke-free candidates in the NOMAS (Northern Manhattan Study), researchers tested the assumption that covert brain infarcts (CBIs) were more likely to be located in noneloquent brain areas vs clinical strokes and that CBI etiological subtypes carry a differential risk of vascular events vs people without CBI. CBI was classified as cardioembolic (ie, known atrial fibrillation), large artery atherosclerosis (extracranial and intracranial), penetrating artery disease, and cryptogenic (no apparent cause). Two hundred thirty-six candidates had CBI at the time of MRI. Findings suggested that CBI could be classified into subtypes with differential results. Certain CBI subtypes like those associated with intracranial large artery atherosclerosis have a high risk of adverse vascular results and could warrant consideration of treatment trials.