Tang MW, et al. - The potential role of class 3 semaphorins in the pathology of rheumatoid arthritis (RA) was evaluated in this trial. Findings suggested that in the synovial tissue of early arthritis subjects who developed the persistent disease, mRNA expression of semaphorins (Sema)3B, Sema3C, Sema3F and Sema3G was notably lower at baseline as compared to the patients with the self-limiting disease after 2 years follow-up. Overall, for modulating the invasive behavior of FLS in RA, the modulation of class 3 semaphorin signaling could be a novel therapeutic strategy.