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Circumcision and risk of febrile urinary tract infection in boys with posterior urethral valves: Result of the CIRCUP randomized trial

European Urology Sep 27, 2021

Harper L, Blanc T, Peycelon M, et al. - According to this clinical randomized trial, circumcision significantly reduces the risk of presenting a febrile urinary tract infection (fUTI) in boys with posterior urethral valves (PUVs).

  • The sample consisted of 91 patients: 49 in group circumcision + antibiotic prophylaxis (CATB) and 42 in group antibiotic prophylaxis alone (ATB).

  • The likelihood of presenting an fUTI was 20% in group ATB and 3% in group CATB.

  • The hazard ratio for developing an fUTI within 2 years in the ATB group was 10.3 when compared with the CATB group.

  • Sixty-four children (70.3%) received a complete follow-up at the age of 2.

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