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Circulatory microRNAs as potential biomarkers for fatty liver disease: The Rotterdam study

Alimentary Pharmacology and Therapeutics Jan 28, 2021

Zhang X, Mens MMJ, Abozaid YJ, et al. - Researchers conducted the study for examining the potential of circulatory microRNAs (miRNAs) as biomarkers of fatty liver disease (FLD) at the population level. Plasma levels of 2,083 miRNAs were measured via RNA sequencing in 1999 candidates from the prospective population‐based Rotterdam Study cohort. The authors observed that plasma levels of several miRNAs were significantly linked to FLD and can be considered as plasma biomarkers of the disease in the population level. There were 17 miRNAs significantly correlated with CT‐based FLD, and four were significantly correlated with hepatic steatosis (miR‐193a‐5p, miR‐122‐5p, miR‐378d and miR‐187‐3p), while three were nominally correlated with liver fibrosis (miR‐193a‐5p, miR‐122‐5p and miR‐193b‐3p).  

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