Purdue MP, et al. - In this case-control study (235 cases, 235 controls) nested within the CLUE-I and CLUE-II cohorts (which enrolled participants in 1974 and 1989 respectively in Washington County, MD), researchers addressed the etiologic relevance of the previously observed association of elevated serum sCD27 and sCD30 from a single banked sample with future non-Hodgkin lymphoma risk. A subset of 102 cases and 102 controls with two banked pre-diagnostic samples each, collected fifteen years apart, were analyzed. According to findings, sCD27 was suggested as a disease marker for NHL. The results also showed that elevated circulating sCD30 was a marker of increased NHL susceptibility.