Schmidt I, Mothi SS, Wilson P, et al. - This study unveiled various plasma protein biomarkers related to kidney disease histopathology as well as adverse clinical results in people with a diverse set of kidney diseases.

• In this prospective cohort analysis of 549 persons with biopsy-verified kidney diseases and semi-quantitative assessment of histopathology, a multi-marker panel of 225 circulating plasma proteins was measured via a proteomics assay.

• Experts identified 57 proteins were linked with different histopathologic lesions, after multivariable adjustment and correction for multiple testing.

• Kidney injury molecule-1 and V-set and immunoglobulin domain-containing protein 2 were revealed as the top performing markers positively related to acute tubular injury and interstitial fibrosis and tubular atrophy, respectively.

• There were 30 proteins that were significantly related to kidney disease progression and 35 were associated with death.

• Placental growth factor (HR per doubling 5.4) and BMP and Activin Membrane Bound Inhibitor (HR 3.0) were the top performing markers for kidney disease progression.

• For death, the top performing markers included TRAIL-receptor-2 (HR 2.9) and CUB Domain Containing Protein-1 (HR 2.4).