Ma J, Lin X, Chen C, et al. - In the present study, the researchers sought to assess the differentially expressed miRNAs in the bone tissue and serum of osteoporotic women with aging. MiRNAs GeneChip and real-time PCR were used in bone tissues of 21 osteoporotic women aged 60–69 years and 80–89 years to test differently expressed miRNAs. Identified miRNAs were identified in the serum of the validation cohort, consisting of 14 healthy premenopausal women and 86 postmenopausal women with osteopenia or osteoporosis. In initial screening, 24 miRNAs displayed the highest differential expression in osteoporotic women's bone tissues. Among them, four miRNAs were detected both in the bone tissue and serum in the validation cohort. According to findings, miR-181c-5p and miR-497-5p are included in bone metabolism and linked to progressive bone loss of due to osteoporosis, indicating that circulating miR-181c-5p and miR-497-5p might act as potential biomarkers for monitoring the impacts of antiosteoporotic therapies or the diagnostic approach.