Papadaki C, et al. - Whether plasma micro-RNA (miR)-21, miR-23b, miR-190, miR-200b and miR-200c, related to dormancy and metastasis, can serve as predictors of the outcome of patients with early breast cancer was investigated. Researchers used RT-qPCR to assess miRNAs in plasma attained prior to adjuvant chemotherapy. They also correlated miRNA expression, classified as high or low according to median values, and relapse and survival. To determine miRNA sensitivity and specificity, they generated receiver operating characteristic (ROC) curves. Findings showed differential expression of circulating miRNAs among relapsed and non-relapsed patients with early breast cancer. Moreover, circulating miRNAs enabled prediction of breast cancer recurrence many years before its clinical detection. Overall, miRNAs represent potential circulating biomarkers in early breast cancer.