Al-Rawaf HA - In this study, researcher characterized the circulating microRNAs (miRNAs) profile for adolescence and its relationship with the circulating levels leptin and adiponectin according to a specific degree of obesity. In adolescents with severe obesity, circulating miRNAs exhibited a significant correlation with plasma levels of adipokines; adiponectin, leptin, and L/A ratios. Findings suggested an association of regulation of miRNAs expression with adipokines and other related metabolic syndrome factors. The authors suggested that early detection of changes in circulating miRNAs profiles may contribute to identifying obese children/adolescents with potentially severe metabolic syndrome.