Al-Rawaf HA - Given the pivotal role of circulating microRNAs (miRNAs) as biomarkers in the pathogenesis of obesity, researchers characterized the circulating miRNA profile for adolescences and its correlation with circulating levels leptin (L) and adiponectin (A) according to specific degree of obesity. They identified at least 10 circulating miRNAs among 250 morbidly obese adolescents, including increased concentrations of miRNAS; miR–142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p, miR-520c-3p, miR-146a, and miR-15a. These were noted to have a strong correlation with measures of BMI, WHtR, adipokines; adiponectin, leptin, L/A ratio, and other MS related biomarkers such as FBS, insulin, HOMA-IR, C-peptide, and circulated plasma lipids such as TG, HDL-C, and LDL-C. Early detection of fluctuations in circulating miRNAs profiles could have promise for identifying obese children or adolescents who may suffer from severe metabolic syndrome.