Fouani FZ, Reza F, Moradi N, et al. - Given a high risk of developing a myriad of endocrinologic and metabolic derailments among patients diagnosed with polycystic ovary syndrome (PCOS) and the potential of Meteorin-like protein (Metrnl), a newly discovered adipokine, to counteract the metaflammation, researchers here examined if and how serum Metrnl levels are associated with homocysteine, hs-CRP, and some components of metabolic syndrome in PCOS related recurrent pregnancy loss (RPL) and infertile PCOS patients. In this case-control study, inclusion of 120 PCOS patients (60 PCOS-RPL and 60 infertile) and 60 control was performed. PCOS patients had lower serum Metrnl levels compared with controls. In addition, PCOS group vs controls had lower serum adiponectin levels but had significantly high free testosterone, fasting insulin, HOMA-IR, homocysteine, and hs-CRP. Furthermore, serum Metrnl associated with BMI, adiponectin, and homocysteine in controls, and inversely associated with FBG, fasting insulin, and HOMA-IR in PCOS group and subgroups. Besides, it had inverse correlation with hs-CRP in control, and PCOS group and subgroups. Findings here indicate that Metrnl is possibly involved in the pathogenesis of PCOS and RPL.