Yang Y, Wu J, Wang X, et al. - Researchers conducted this cross-sectional study with the aim to determine if in humans, serum levels of fibroblast growth factor 21 (FGF21) and fatty acid-binding protein-4 (FABP4) are linked with missed abortion (MA). In the discovery cohort, they included 78 patients with MA and 79 healthy pregnant women matched for maternal age and body mass index from a prospective cohort. Patients with MA had significantly and independently elevated circulating levels of FGF21 and FABP4 relative to the levels in the healthy controls. A single measurement of FGF21 serum level led to effective discrimination of MA with an area under the receiver operating characteristics curve of 0.80. Overall findings support the correlation of serum levels of FGF21 and FABP4 with MA. They suggest the potential value of circulating FGF21 as a biomarker for the identification of MA.