Le Marchand L, Wilkens LR, Castelfranco AM, et al. - Given a likely greater role of visceral adipose tissue (VAT) vs subcutaneous fat in increasing cancer risk, researchers undertook a cross-sectional analysis to create a VAT prediction score by regression equations averaged across 100 LASSO models. A total of 1,801 older adults in the Multiethnic Cohort (MEC) were included. In case-control investigations of the postmenopausal breast (950 cases-control pairs) and colorectal (831 case-control pairs) cancer in an independent sample in MEC, experts used the score as a substitute for VAT. The final score, including 9 biomarkers, BMI and height, explained 11% and 15% more of the variance in VAT vs BMI alone in males and females, respectively. For VAT > 150 cm², the area under the receiver operator curve was identified to be 0.90 and 0.86 in men and in women, respectively. Experts identified a link of VAT score with the risk of breast cancer but not with colorectal cancer, although a link was indicated for this cancer after dismissing cases that happened within 7 years of blood draw. Overall, VAT score enabled risk prediction for postmenopausal breast cancer and affords a tool to perform risk evaluation in diverse populations.