Bernard H, Turner PJ, Ah‐Leung S, et al. - Given that a key determinant of allergic reactions may be bioaccessibility of food allergens, so, researchers sought to construct a protocol enabling the identification of Ara h 6 (the major peanut allergen) in the bloodstream after ingestion of low quantities of peanut and to compare Ara h 6 bioaccessibility by food matrix. They also evaluated for disparities in absorption in healthy vs peanut‐allergic volunteers. They created a blood pretreatment integrating acidic shock and thermal treatment, which was applied to blood samples obtained from human volunteers (n = 6, healthy controls; n = 14, peanut‐allergic patients) at several time‐points after ingestion of rising levels of peanut incurred in different food matrices (cookies, peanut butter and chocolate dessert). In samples from all volunteers, Ara h 6 was identified after ingestion of 300‐1000 mg peanut protein, although the kinetics of passage were different between individuals and matrices. Overall, findings demonstrated the dependence of the kinetics and intensity of Ara h 6 passage in bloodstream on both individual and food matrix. Higher absorption rate seemed to be exhibited by peanut‐allergic patients, the clinical significance of which warrants further assessment.