Circulating advanced glycation endproducts and long-term risk of cardiovascular mortality in kidney transplant recipients
Clinical Journal of the American Society of Nephrology Oct 14, 2019
Sotomayor CG, Gomes-Neto AW, van Londen M, et al. - In this prospective cohort analysis, researchers examined the link of advanced glycation endproducts (AGEs) (ie, Nε-[Carboxymethyl]lysine (CML) and Nε-[Carboxyethyl]lysine (CEL), measured by tandem mass spectrometry) with cardiovascular mortality among stable kidney transplant recipients. Whether inflammatory, oxidative stress and endothelial dysfunction biomarkers could mediate this link was also inquired. This study included 555 kidney transplant recipients of age 51 ± 12 years, 56% were men. Findings revealed independent association of circulating levels of AGEs with long-term risk of cardiovascular mortality in the participants. Nearly 35% of the link of CML and CEL with cardiovascular mortality was consistently explained by free thiol groups and soluble vascular cell adhesion molecule-1, as revealed in mediation analyses.
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