Cao Y, Xie X, Li M, et al. - Given abnormal upregulation of circular RNA HIPK2 (circHIPK2) in serum of ovarian cancer (OvCa) patients, there is still a lack of clarity regarding its role in cisplatin (DDP) resistance, therefore, researchers explored this herein. Using quantitative reverse transcription PCR and Western blotting, expression of cirHIPK2, microRNA (miR)-338-3p and chromatin target of protein arginine methyltransferase (CHTOP) was identified. Experts found upregulated expression of circHIPK2 and CHTOP, and downregulated miR-338-3p in human DDP-resistant OvCa tumors and cells. Not only apoptosis could be promoted by blocking circHIPK2 but it could also suppress the 50% inhibitory concentration (IC50) of DDP, cell proliferation, cell cycle entrance, migration as well as invasion in SKOV3/DDP and A2780/DDP cells. In the light of the findings of this study, a likely role of circHIPK2 as a tumor promoter in OvCa was suggested as well as its link with DDP resistance was shown. Suppression of DDP-resistant OvCa might be brought about by silencing circHIPK2 via regulating miR-338-3p/CHTOP axis.