Wu F, et al. - Researchers examined the role of a novel circular RNAs (circRNAs) and associated molecular mechanism in cervical cancer (CC) cells. In this research, they selected CircRNA circAGFG1 with ID of hsa_circ_0058514 for investigation. They designed recue assays to verify the role of circAGFG1/miR-370-3p/RAF1 axis in CC cell activities. Using qRT-PCR, they identified abundant levels of circAGFG1 in CC cells in comparison with normal cervical cell End1/E6E7. Findings revealed the inhibitory effect of decreased circAGFG1 level on the proliferative and migratory abilities of CC cells. By absorbing miR-370-3p, CircAGFG1 could increase RAF1 expression, thereby stimulating RAF/MEK/ERK pathway. circAGFG1 increases CC cell proliferation and migration via intensifying the activity of RAF/MEK/ERK pathway by sponging miR-370-3p and further regulating RAF1. Novel evidence thus gained in this work indicates a vital regulatory role of circAGFG1 in cervical cancer proliferation and migration, giving great promise to utilize it as a potential biomarker for diagnosis and therapy in CC treatment.