Liu P, Wang M, Tang W, et al. - In non-small-cell lung carcinoma (NSCLC), researchers, wanted to clarify the molecular mechanism behind the anti-tumor role of Celastrol (Cela), a natural compound with anti-tumor activity in many cancer cells. They assessed cell cycle progression and apoptosis via flow cytometry. They examined the functions of Cela and circular RNA SATB homeobox 2 (circ_SATB2) in NSCLC progression in vivo by conducting xenograft tumor assay. It was found that malignant behaviors of NSCLC cells were hindered by Cela. Downregulation of circ_SATB2 level in NSCLC cells was induced by Cela. MiR-33a-5p (microRNA-33a-5p) was identified as a target of circ_SATB2, and E2F7 (E2F transcription factor 7) was confirmed as a target of miR-33a-5p. Overall, findings revealed that NSCLC development was suppressed by Cela by regulating circ_SATB2/miR-33a-5p/E2F7 signaling cascade.