Roehm B, et al. - It remains unknown if smoking cessation restores angiotensin converting enzyme inhibition (ACEI)-related kidney protection in nondiabetic chronic kidney disease (CKD). In this current study, it was demonstrated that possibly by restoring kidney-protective impacts of ACEI via reductions in kidney angiotensin II (AII) and oxidative stress, smoking cessation versus continued smoking ameliorated estimated glomerular filtration rate (eGFR) decline in nondiabetic CKD treated with ACEI.