Lee YC, et al. - In 2002-2015, researchers examined trends in the use of chronic opioids in rheumatoid arthritis (RA) patients and identified clinical predictors. They identified RA patients from the Corrona registry. They observed that chronic opioid use doubled from 2002 to 2015 among RA patients. The strongest predictors of chronic opioid use were pain and antidepressant use. Strategies for stringent control of RA disease activity and management of pain and depression should be research priorities in order to curb the rise in chronic opioid use.