Oh TK, Song IA., et al. - In non-cancer patients experiencing chronic pain, researchers conducted this population-based historical cohort study was to determine if chronic opioid therapy is related to a greater risk of cancer. Participants were members of the South Korean adult population with data in the National Health Insurance Service. Patients with a diagnostic code of M00-M99 (musculoskeletal system and connective tissue diseases) as per the International Classification of Diseases, 10th revision, in 2010, were included. Chronic opioid users were defined as those prescribed a continuous supply of any opioid drug for ≥ 90 days. Overall 351,701 patients were included, 25,153 (7.2%) of whom were chronic opioid users. In non-cancer patients experiencing chronic pain. Findings revealed an increased risk of cancer in correlation with chronic opioid therapy; in chronic strong opioid users, this link was more pronounced. The risk of cancer in chronic opioid users was 1.20-fold higher vs controls, using a multivariable time-dependent Cox regression model. Caution is encouraged while assessing the link between chronic opioid use and cancer risk is advised because the findings might have been impacted by unmeasured and potential confounders.