Mao W, et al. - A prospective study is conducted to assess functional and pathological alterations in chronic kidney disease (CKD) by applying Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). The outcome of this study suggests that the IVIM-DWI could be feasible for noninvasive assessment of renal function and pathology of CKD, particularly in the detection of renal insufficiency at an early stage.