Chao CT, Wang J, Huang JW, et al. - Since musculoskeletal degeneration is central to frailty development, researchers explored the association between baseline osteoporosis and the subsequent frailty risk in individuals with diabetic kidney disease (DKD). Researchers distinguished 12,027 individuals having DKD with osteoporosis and 24,054 propensity score-matched controls having DKD but without osteoporosis from the Longitudinal Cohort of Diabetes Patients in Taiwan (n = 840,000). The primary outcome included incident frailty on the basis of a modified FRAIL scale. They evaluated the association between osteoporosis at baseline and incident frailty in these patients using the Kaplan-Meier technique and Cox proportional hazard regression. The evidence demonstrated that chronic kidney disease-related osteoporosis is correlated with a higher risk of incident frailty in patients with DKD.