Kleppe A, et al. - Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Herein, researchers aimed to define and validate a novel prognostic biomarker for the automatic detection of heterogeneous chromatin organisation. They interpreted that the marker of chromatin heterogeneity can be reliably assessed in routine clinical practice and could be used to objectively assist decision making in a range of clinical settings because they observed consistent prognostic prediction of Nucleotyping in different biological and technical circumstances. An immediate application would be to identify high-risk patients with stage II colorectal cancer who might have greater absolute benefit from adjuvant chemotherapy.