Giambelluca S, Verlato G, Simonato M, et al. - In the present study, the researchers sought to evaluate the impact of chorioamnionitis on metabolite and lipid profiles of epithelial lining fluid in preterm newborns with respiratory distress syndrome (RDS). Participants in the study were 30 newborns with RDS, born from mothers with or without histological chorioamnionitis (HCA): HCA+, N = 10; HCA−, N = 20. The production of lipid mediators in the sense of an ongoing inflammatory status in HCA+ babies was suggested by untargeted lipidomics of tracheal aspirates. The effect of chorioamnionitis on the composition of the epithelial lining fluid, however, needs to be further studied in a larger group of infants.