van den Berg EH, et al. - Researchers determined the association of cholesterol efflux capacity (CEC; a key metric of high density lipoprotein [HDL] function) with non-alcoholic fatty liver disease (NAFLD). Study participants included 639 subjects [454 men; 36 subjects with type 2 diabetes mellitus (T2D); 226 with metabolic syndrome (MetS)], participating in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. In this study, they used a Fatty Liver Index (FLI) ≥ 60 as a proxy of NAFLD. Findings demonstrated an association between impaired CEC and NAFLD, as inferred from a FLI≥60, even when considering lower HDL cholesterol and enhanced low-grade chronic inflammation. In NAFLD patients, reduced CEC could contribute to accelerated cardiovascular disease.