Cahill LE, et al. - Researchers investigated healthy middle age and older men not on treatment influencing blood lipid levels in this nested case-control study in order to simultaneously evaluate cholesterol efflux capacity (CEC) (using J774 cells) and plasma high-density lipoproteins (HDL) cholesterol (HDL-C) levels as predictors of coronary heart disease (CHD). From the Health Professionals Follow-Up Study, risk-set sampling of participants free of disease at baseline was used and cases (n=701) were matched to controls 1:1 for age, smoking, and blood sampling date. Findings revealed a correlation between CEC and HDL-C. They concluded that CEC may not be able to predict CHD independently of HDL-C in a cohort of generally healthy men.