Prout AJ, et al. - Researchers used a nationally representative sample to study the contemporary epidemiology of pediatric sepsis in children with chronic disease and the contribution of chronic diseases to mortality using mixed effects logistic regression. A total of 16,387 admissions, representing 14,243 unique patients, were for sepsis. They found that ≥1 chronic disease was present in more than 2 of 3 children admitted with sepsis. A higher in-hospital mortality was observed in these patients, compared with previously healthy patients. Overall, the greatest burden of sepsis in hospitalized children was reported in pediatric patients with chronic disease.