Braun C, et al. - This study encompassed an examination of the bone microstructure with the aid of high-resolution peripheral quantitative tomography (HR-pQCT) in children and teenagers with cystic fibrosis. A comparison was performed with regard to age-, puberty-, and gender-matched healthy volunteers (HVs). The enrollees with good nutritional and lung function status, bone microstructure analyzed through HR-pQCT did not exhibit severe affection. A possible relationship was brought to light between minimal microstructure abnormalities observed at the tibial level with the cystic fibrosis transmembrane conductance regulator defect alone. In order to determine the long-term consequences of such impairment advanced studies were warranted.