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Childhood patterns of overweight and wheeze and subsequent risk of current asthma and obesity in adolescence

Paediatric and Perinatal Epidemiology Mar 30, 2021

Aris IM, Sordillo JE, Rifas‐Shiman SL, et al. - Using latent class growth models (LCGM) and inverse probability weighting (IPW) of marginal structural models, researchers sought to explore the extent to which the presence of overweight across childhood was correlated with early adolescent current asthma, and conversely of repeated measures of wheeze across childhood with early adolescent obesity. The baseline sample included 1,277 children registered in a Boston‐area cohort with BMI or wheeze at age 1 year and no missing covariates. Both approaches' point estimates suggest a link between “persistent” childhood overweight and adolescent asthma, as well as “persistent” childhood wheeze and adolescent obesity. The LCGM results were more powerful and precise, whereas the IPW results were less conclusive, with wider 95% confidence intervals that included the null. The precision gained from LCGM may come at the expense of bias, and using both approaches helps to shed light on this tradeoff.

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