Yrondi A, et al. - Researchers investigated how childhood maltreatment, severity of depression in unipolar treatment-resistance depression (TRD) sample, and patient outcomes after 1 year of follow-up are associated. From the French network of TRD expert centers, recruitment of patients was done for a prospective cohort. The Montgomery–Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR) was used to assess depressive symptom severity. The Childhood Trauma Questionnaire (CTQ) was used to evaluate childhood maltreatment. Between 2012 and 2019, the CTQ was filled by 256 patients at baseline. The MADRS score was noted to be linked with the CTQ score at baseline. Further, QIDS was also linked with CTQ scores. MADRS was noted to be linked with physical and sexual abuse, while QIDS with physical abuse and physical neglect when different subtypes of childhood maltreatment were considered. These findings suggest a significant relationship between the severity of depressive disorders and childhood maltreatment in the TRD population. Individuals with less likelihood to go into remission after treatment could be recognized via using information about a history of childhood maltreatment.