Mikkola TM, et al. – The purpose of this study was to examine the associations between body size at birth and childhood growth with bone area, bone mineral content (BMC), and areal bone mineral density (aBMD) in early old age. For obtaining larger skeleton and consequently higher bone mass, optimal growth in height in girls was essential. However, when predicting bone mineral mass among elderly women, information on early growth does not improve prediction beyond that predicted by current height and weight.

Methods

• For this study, a subgroup of women (n = 178, mean 60.4 years) from the Helsinki Birth Cohort Study, born 1934–1944, participated in dual–energy X–ray absorptiometry (DXA) measurements of the lumbar spine and hip.
•  Height and weight at 0, 2, 7, and 11 years, obtained from health care records, were reconstructed into conditional variables representing growth velocity independent of earlier growth. 
• Weight was adjusted for corresponding height.
• For multiple confounders, linear regression models were adjusted.

Results

• Findings revealed that birth length and growth in height before 7 years of age were positively associated with femoral neck area (p < 0.05) and growth in height at all age periods studied with spine bone area (p < 0.01). 
• Growth in height before the age of 7 years was associated with BMC in the femoral neck (p < 0.01) and birth length and growth in height before the age of 7 years were associated with BMC in the spine (p < 0.05). 
• Nearly all associations disappeared, after entering adult height into the models.
• Weight gain during childhood was not associated with bone area or BMC, and aBMD was not associated with early growth.