Kim C, et al. - In this prospective cohort study, experts explored if childhood adipose tissue deposition impacts sex hormone profiles in later adolescence. In the Exploring Perinatal Outcomes among Children (EPOCH) Study, 418 children with a mean age of 10.5 (1.5) years at visit 1 and 16.7 (1.2) at visit 2. To evaluate connections between pubertal dehydroepiandrosterone (DHEA), testosterone, and estradiol and childhood-to-puberty rate of change in visceral and subcutaneous adipose tissue, reverse-scale Cox proportional hazard models were used. Investigators found that lower testosterone in boys is linked to more rapid accumulation of fat. These correlations indicate that, in adolescent boys, fat growth impacts androgen profiles. There were no links in boys between fat measure and estradiol or DHEA. No links have been noted in girls between childhood fat or fat accumulation and sex hormones. Due to the fact that fat accumulation is a modifiable risk factor, the results of the study provide a potential target of intervention and time to improve adult health.