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Child-related and parental predictors for thelarche in a general population of girls: The PANIC study

Pediatric Research Feb 20, 2020

Savinainen SE, et al. - Researchers sought for child-related and parental predictors for earlier thelarche in 195 girls aged 6–8 years followed up for 2 years. During 2 years, an increase in the incidence of thelarche was observed by 11% for 1 unit increase in baseline body fat percentage (BF%). A 2.64 times higher incidence of thelarche was observed among girls with a smoking parent vs other girls. BF% largely explain the associations of lower parental education and higher maternal prepregnancy BMI with a higher incidence of thelarche. These findings suggest the independent predictive value of higher BF% and exposure to tobacco smoke for earlier thelarche.
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