van der Kleij HPM, et al. - Authors gauged the immunogenicity, allergenicity and immunotherapeutic efficacy of a well characterized chemically modified peanut extract (MPE) adsorbed to Al(OH)₃. They performed competitive IgE-binding assays and mediator release assays using sera of patients. Reduced allergenicity was demonstrated by an Al(OH)₃ adsorbed MPE vs unmodified peanut extract (PE), while the efficacy of immunotherapy is maintained. In all patients, the IgE-binding and capacity to induce allergic symptoms of MPE was lower compared to PE.