Broeke NC, et al. - In this cross-sectional study involving 10 men with biopsy-proven prostate cancer (PCa), researchers sought to measure the distribution in human PCa of tissue sodium concentration (TSC), proton T2-weighted signal, and apparent diffusion coefficient (ADC) values, and to test the presence of a correlation between regional differences in image metrics and the Gleason grade of histopathologically determined lesions. According to the results of this preliminary study, changes in TSC, evaluated by sodium MRI, are useful in characterizing PCa lesions as a non-invasive imaging assay. Findings suggested that sodium MRI can provide useful additional information on mpMRI, which can assist men in choosing either active monitoring or treatment to make decisions.