Moldovan LI, Tsoi LC, Ranjitha U, et al. - This study was intended to compare and contrast the circRNA expression landscapes in paired lesional and non‐lesional skin from psoriasis and atopic dermatitis (AD) patients relative to skin from unaffected individuals applying high‐depth RNA‐seq data. CircRNAs and their cognate linear transcripts were evaluated applying the circRNA detection algorithm, CIRI2, and in situ hybridization, and Sanger sequencing was applied for validation purposes. Researchers distinguished 39,286 circRNAs among all samples and found that psoriasis and AD lesional skin could be distinguished from non‐lesional and healthy skin based on circRNA expression landscapes. The results of this study demonstrate that circRNA transcriptome of psoriasis and AD share expression features, including a global downregulation relative to healthy skin, but this is most pronounced in psoriasis, and only psoriasis is defined by several circRNAs being dysregulated independently of their cognate linear transcripts. In addition, specific circRNAs could potentially be applied to identify AD from psoriasis.